Cytomegalovirus (CMV) – Medical Definition and Pronunciation



Cytomegalovirus (CMV)

Cytomegalovirus (CMV): A virus that infects 50-85% of adults in the US by age 40 and is also the virus most frequently transmitted to a child before birth. Persons with symptoms have a mononucleosis-like syndrome with prolonged fever and mild hepatitis. Once a person becomes infected, the virus remains alive and usually dormant within that person’s body for life. Recurrent disease rarely occurs unless the person’s immune system is suppressed due to therapeutic drugs or disease. CMV infection is therefore a concern because of the risk of infection to the unborn baby, people who work with children, and immunodeficient people such as transplant recipients and those with HIV. CMV is a member of the herpesvirus group, which also includes herpes simplex virus, varicella-zoster virus (which causes chickenpox) and Epstein-Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. Initial CMV infection, which may have few symptoms, is always followed by a prolonged, inapparent infection during which the virus resides in cells without causing detectable damage or clinical illness. Severe impairment of the body’s immune system by medication or disease consistently reactivates the virus from the latent or dormant state. Infectious CMV may be shed in the bodily fluids of any previously infected person, and thus may be found in urine, saliva, blood, tears, semen, and breast milk. The shedding of virus may take place intermittently, without any detectable signs, and without causing symptoms. Spread of CMV is from person to person. Infection requires close contact with a person excreting the virus in their saliva, urine, or other bodily fluids. CMV can be sexually transmitted. It can also be transmitted via breast milk, transplanted organs and, rarely, blood transfusions. Although the virus is not highly contagious, it has been shown to spread in households and among young children in day care centers. Transmission of the virus is often preventable because it is most often transmitted through infected bodily fluids that come in contact with hands and then are absorbed through the nose or mouth of a susceptible person. Therefore, care should be taken when handling children and items like diapers. Simple hand washing with soap and water is effective in removing the virus from the hands.

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Medical definition of Cytomegalovirus (CMV)

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